Medical representatives face so many issues and problems today in India and globally. There are diverse views in terms of physician actually being respectful to Medical representatives. The doctor’s feels that the medical represents are wasting their time. It is just a 'blaming game' and fingers being pointed at each other. Thus the study was an attempt to understand the real professional challenges faced by the Medical representatives. A structured questionnaire was constructed and the required data was gathered from 85 Medical representatives in Thrissur district. The sampling technique adopted for the study was convenience sampling. The data was analysed and the findings of the research were listed out. It was observed that Medical representatives are facing different problems. Among these non-receipt of salary in time and poor product quality are the serious challenge for them. Based on the details of the study it was suggested to concentrate on MRs professional and personal growth by enhancing their job related skills. The details of the study show that the interaction between medical representatives and doctors has to be smoothened.