A diagnosis of cancer along with its treatment can challenge patients to deal with a variety of stressors. Although there is a plethora of studies assessing patient’s quality of life and adjustment to cancer, we know very little about personality factors that predict the way in which patients cope with cancer. The objective of this study was to investigate the relationship of personality traits with the coping strategies in a sample group of cancer patients. The sample of the study consisted of 286 cancer patients who were selected purposively from Department of Radiation Oncology, Government Medical College and Associated Hospitals, Karan Nagar, Srinagar, Florence Hospital, Chanapora Srinagar, Noora Hospital, Zainakote, Srinagar. The participants completed the sample survey packets comprised of NEO Five-Factor Inventory (NEO-FFI) (Costa, P & McCrae, R, 1992), and Brief Cope, (Carver, 1997). The results of the study showed that personality traits viz. Neuroticism, Extraversion, Openness and Conscientiousness are significantly correlated with active-adaptive coping whereas there is an insignificant correlation between Agreeableness and active-adaptive coping. Further the results showed that avoidance coping is significantly correlated with personality traits viz. Neuroticism, Extraversion, Openness, Agreeableness and Conscientiousness. The findings of this study can provide support for personality traits and coping strategies as targets of intervention and help both clinicians and patients in dealing with the trauma of cancer.