Background: The postnatal (postpartum) period begins immediately after childbirth and extends for six weeks. This phase is critical, involving significant physical and psychological adjustments for both mother and newborn. While professional care is vital, the knowledge of primary caregivers at home is essential for long-term health outcomes.

Aim: The aim of the study is to evaluate the effectiveness of structured teaching program on knowledge regarding .postnatal care among caretakers of postnatal mothers.

Methodology: A quantitative research approach with a one-group pre-test post-test design was used to evaluate the effectiveness of a structured teaching programme, 100 caregivers were selected from a private hospital, Coimbatore. Data were collected via a semi-structured interview schedule for demographic variables and a structured questionnaire to assess postnatal care knowledge. Data were analyzed using descriptive and inferential statistics.

Results: The study revealed that the majority of caregivers had poor to average knowledge in the pre-test, whereas after the structured teaching programme, 70% achieved good knowledge. The mean knowledge score significantly increased from 7.2 ± 2.8 to 12.6 ± 2.1. The difference was found to be highly significant (t = 21.6, p < 0.001). Significant associations were observed between post-test knowledge and age, education, and previous knowledge.

Conclusion: The structured teaching programme was effective in significantly improving caregivers’ knowledge regarding postnatal care, highlighting the importance of educational interventions in enhancing maternal and newborn health outcomes.